In this issue of Cell Host & Microbe, O'Gorman et al. (2010) identify a key role for early TLR2-mediated IL-6 production and STAT3 activation in generating protective immunity against poxviruses. These findings highlight the importance of early inflammatory cytokine production in antiviral defense and have implications for enhancing vaccination efficacy. © 2010 Elsevier Inc.
Ivashkiv, L. B. (2010, August 19). STAT activation during viral infection in vivo: Where’s the interferon? Cell Host and Microbe. Cell Press. https://doi.org/10.1016/j.chom.2010.07.011