A key question in synaptic physiology is what determines the release probability of a synaptic vesicle. In this issue of Neuron, Wadel et al. shed UV light on this problem, finding that hard-to-release vesicles are too far from Ca2+ channels. © 2007 Elsevier Inc. All rights reserved.
Price, G. D., & Trussell, L. O. (2007, February 15). Good Players Left on the Sidelines: Why Some Synaptic Vesicles Don’t Get in the Game. Neuron. https://doi.org/10.1016/j.neuron.2007.02.003