Immunogenicity studies of synthetic peptides from different regions of VP1 protein of foot-and-mouth disease virus strain A22 revealed the following active fragments: 39-61, 50-69, 135-159, 175-189, 170-189 and 197-213. Testing of virus neutralizing antibody production in rabbits primed by peptides and then inoculated by the virus showed that only peptides 135-159 and 170-189 were able to induce the functional T-cell helper activity. Localization of virus-specific T-cell recognition sites in sequences 135-159 and 170-189 was confirmed in in vitro recognition experiments of the virus by peptide activated mice lymphocytes. © 1993.
Volpina, O. M., Gelfanov, V. M., Yarov, A. V., Surovoy, A. Y., Chepurkin, A. V., & Ivanov, V. T. (1993). New virus-specific T-helper epitopes of foot-and-mouth disease viral VP1 protein. FEBS Letters, 333(1–2), 175–178. https://doi.org/10.1016/0014-5793(93)80399-F