Synthesis of 1-(4-trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-rthiazol-4-yl)- 1H-pyrroles via chain heterocyclization

Abstract

The title compounds, (4-trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R- thiazol- 4-yl)-1H-pyrroles, were prepared in four steps starting from commercially available 4- trifluoromethoxyaniline. The pyrrole (second ring) was added in one step using the Paal- Knorr method. The thiazole (third ring) was added in three steps using chloroacylation with chloroacetonitrile followed by heterocyclization with thioamides/thioureas. © 2010 by the authors.