Capnocytophaga ochracea: Characterization of a plasmid-encoded extended- spectrum TEM-17 β-lactamase in the phylum Flavobacter-Bacteroides

Abstract

A plasmid-encoded extended-spectrum TEM β-lactamase with a pI of 5.5 was detected in a Capnocytophaga ochracea clinical isolate. The bla gene was associated with a strong TEM-2 promoter and was derived from bla(TEM-1a) with a single-amino-acid substitution: Glu104→Lys, previously assigned to TEM- 17, which is thus the first TEM β-lactamase to be reported in the phylum Flavobacter-Bacteroides.