Intravenous midazolam dose ranges in older patients sedated for oral surgery - A preliminary retrospective cohort study

Abstract

Aim The aim of this study was to investigate differences in the titrated midazolam doses in older patients undergoing oral surgery procedures under intravenous sedation.Method The records of 50 patients aged 40-92 years who had undergone oral surgery procedures under intravenous sedation at Kings College Hospital between May 2008 and February 2009 were selected at random in each of the age groups: 40, 50, 60, 70 or 80+.Results The mean dose for patients over the age of 70 (2.8 mg) was 50% less than the mean dose for those under the age of 70 (5.7 mg).Conclusions Our study found a correlation between the age of the patient and the dose of midazolam required for sedation before oral surgery procedures, with, on average, older patients requiring less midazolam. A range of doses are required in any age group, but the range decreases as age increases. © 2014 Macmillan Publishers Limited. All rights reserved.