Pharmacokinetics of a single oral dose of 1.5-mg levonorgestrel when administered as 750-μg tablets or as 30-μg minipills

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Abstract

We examined the pharmacokinetics of a single dose of 1.5 mg of levonorgestrel when administered orally in two different formulations: two tablets of 0.75 mg or 50 minipills of 30 μg of levonorgestrel. Bioavailability of levonorgestrel with minipills was comparable to that with levonorgestrel tablets. These findings suggest that levonorgestrel-containing minipills can be considered as an alternative to standard levonorgestrel tablets for use in emergency contraception. © 2007 American Society for Reproductive Medicine.

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Devoto, L., Espinoza, A., Muñoz, A., Fuentes, A., & von Hertzen, H. (2007). Pharmacokinetics of a single oral dose of 1.5-mg levonorgestrel when administered as 750-μg tablets or as 30-μg minipills. Fertility and Sterility, 88(4), 976–977. https://doi.org/10.1016/j.fertnstert.2006.12.088

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