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Blockade of PD-1 immunosuppression boosts CAR T-cell therapy

  • John L
  • Kershaw M
  • Darcy P
OncoImmunology (2013) 2(10) e26286
DOI: 10.4161/onci.26286
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Abstract

The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading to enhanced tumor eradication.

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John, L. B., Kershaw, M. H., & Darcy, P. K. (2013). Blockade of PD-1 immunosuppression boosts CAR T-cell therapy. OncoImmunology, 2(10), e26286. https://doi.org/10.4161/onci.26286

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