The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. VDR regulates the expression of numerous genes involved in calcium/phosphate homeostasis, cellular proliferation and differentiation, and immune response, largely in a ligand-dependent manner. To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets. This review focuses on the tissue- and cell type-specific distribution of VDR throughout the body. © 2011 Elsevier Inc. All rights reserved.
CITATION STYLE
Wang, Y., Zhu, J., & DeLuca, H. F. (2012, July 1). Where is the vitamin D receptor? Archives of Biochemistry and Biophysics. https://doi.org/10.1016/j.abb.2012.04.001
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