Highly regioselective and chemoselective titanocene mediated Barbier-type allylation reactions

Abstract

Titanocene carboxylate 1 is an excellent chemoselective reagent for unprecedented α-regioselective Barbier-type reactions. It constitutes the first titanocene(III) able to tolerate epoxides and readily reduced carbonyl compounds, such as aromatic and α,β-unsaturated aldehydes. © 2014 The Royal Society of Chemistry.