The peptidoglycan hydrolase of staphylococcus aureus bacteriophage Ψ11 plays a structural role in the viral particle

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Abstract

The role of virion-associated peptidoglycan hydrolases (VAPGHs) in the phage infection cycle is not clear. gp49, the VAPGH from Staphylococcus aureus phage φ11, is not essential for phage growth but stabilizes the viral particles. φ11δ49 phages showed a reduced burst size and delayed host lysis. Complementation of gp49 with HydH5 from bacteriophage vB_SauS-phi-IPLA88 restored the wild-type phenotype. © 2013, American Society for Microbiology.

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Rodríguez-Rubio, L., Quiles-Puchalt, N., Martínez, B., Rodríguez, A., Penadés, J. R., & García, P. (2013). The peptidoglycan hydrolase of staphylococcus aureus bacteriophage Ψ11 plays a structural role in the viral particle. Applied and Environmental Microbiology, 79(19), 6187–6190. https://doi.org/10.1128/AEM.01388-13

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