Observations on the pharmacology of a eugenol derivative, G.29.505

Abstract

Summary: A derivative of eugenol, G.29.505, was tested for its pharmacological properties on isolated kitten hearts, on conscious cats, on cats anaesthetized with chloralose and on decerebrate and spinal cats.Its effects on consciousness and spinal reflexes, on the neuromuscular junction, on blood pressure and pulse rate, and on frequency and depth of ventilation were tested.It was shown that when given intravenously G.29.505 produced rapid anaesthesia of short duration preceded by transient excitement associated with hypotension and respiratory stimulation. The hypotension was followed by adrenaline release, and in some instances pulmonary oedema developed after repeated injections of the drug.It was established that the hypotension and the pulmonary oedema were due to the solvent and not to the drug itself which was, however, responsible for both the adrenaline release and a transient respiratory stimulation. © 1962 John Sherratt and Son.