Quality of life among patients on MDR-TB treatment in a district tuberculosis centre of a metropolitan city

Abstract

Background: MDRTB is a global health concern with its current prevalence in India being 2.3% and 17.2% respectively among newly diagnosed and previously treated cases. Besides its clinical impact, the disease affects the QOL of patients suffering from MDR-TB. The objective of the study was to assess the quality of life among MDR-TB cases in comparison with non-MDR TB cases and TB cured subjects (Category I, RNTCP).Methods: A cross sectional study was conducted in all the 14 TUs under District Tuberculosis Centre of Municipal Corporation of Bengaluru (BBMP). Study subjects comprised of 52 MDR-TB Cases, 53 Non-MDR-TB cases and 54 Category I TB cured subjects. WHOQOL BREF questionnaire was used to assess the QOL among study subjects. Median [IQR] scores of QOL in each of the domains among various groups were compared using Kruskal Wallis test. P<0.05 was considered as statistically significant.Results: Median age among MDRTB cases was 35 years [IQR: 26-50] whereas it was 37 years [IQR: 28-47] among Non MDRTB cases and 30.5 years [IQR: 22-45] among TB cured subjects. Out of 52 MDRTB cases, 26(50%) were females compared to 14 (26.4%) among Non MDRTB cases and 26(48.1%) among TB cured subjects (p=0.0024). As compared to non MDRTB cases, physical and environmental domains’ scores of MDRTB cases were significantly low (p=0.01 and p=0.001 respectively).Whereas, as compared to TB cured subjects, physical and psychological domains’ scores of MDRTB cases were significantly low (p<0.001 and p<0.001 respectively).Conclusions: The QOL of patients suffering from TB is affected and the impact is even worse in MDRTB. Hence prompt treatment of TB and early diagnosis of MDRTB will reduce the disease severity and improve the QOL.