The effect of a 12-week exercise or weight loss program in overweight and obese patients with coronary artery disease: Results from the randomized controlled trial CUT-IT.

  • LR P
  • R O
  • A J
  • et al.
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Abstract

Background: Physical inactivity and overweight are major risk factors in coronary artery disease (CAD); thus, physical activity and weight loss are central in secondary prevention. These interventions are well-documented; however, a head-to-head comparison is lacking. Methods: 70 participants with CAD, BMI > 28 kg/m2 and no diabetes were randomized (1:1) to 12 weeks' supervised aerobic interval training (AIT) at 90% maximal heart rate 3 times/week or weight loss using a low energy diet (LED, 800-1000 kcal/day). The intervention was evaluated by a cardiopulmonary exercise test, body weight, dual X-ray absorptiometry to assess body fat mass (BF), waist/hip-ratio, resting heart rate and blood pressure. Further, 15 and 19 participants in the AIT and LED group, respectively, underwent MRI to assess abdominal visceral and subcutaneous fat. Results: 57 (81.4%) participants were men, median age was 63 (IQ range 58-67) years, median BMI was 31.3 (IQ range 29.7-33.7) kg/m2 and mean VO2peak was 32.3 (SD 6.4) ml/kg fat free mass*min. No between-group difference on relevant baseline data was seen. After 12 weeks 34 and 31 participants were examined in the LED and AIT group, respectively. Results of the intervention are presented (+ SEM) the table. Conclusion: An LED is superior regarding weight loss and reducing BF, subcutaneous and visceral abdominal fat, while AIT is better in improving physical fitness. Further analyses will compare effects on cardiovascular and metabolic risk markers and long-term sustainability. (Table Presented).

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LR, P., R, O., A, J., A, A., E, C., L, S., … E, P. (2014). The effect of a 12-week exercise or weight loss program in overweight and obese patients with coronary artery disease: Results from the randomized controlled trial CUT-IT. In Journal of the American College of Cardiology (Vol. 63, p. A1301). https://doi.org/10.1016/S0735-1097%2814%2961301-2

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