Background . Heartburn and acid reflux (HB/RF) are associated with increased severity of nausea and vomiting. The ability of acid-reducing drugs to reduce symptoms of nausea and vomiting of pregnancy has not been previously tested. Objective . To determine whether acid-reducing pharmacotherapy decreases the severity of NVP symptoms. Methods . We studied a cohort of women experiencing NVP, who were also experiencing HB/RF. Women were counseled to commence acid-reducing pharmacotherapy. The effectiveness of the acid-reducing medication in decreasing symptoms of both HB/RF and NVP was measured. Results . Acid-reducing drugs resulted in significant decreases in PUQE ( 9.6±3.0 to 6.5±2.5 , P<.0001 ) and well-being scores from the initial ( 4.0±2.0 ) to the follow-up interview ( 6.8±1.6 , P<.0001 ). After intervention with acid-reducing pharmacotherapy, a reduction in acid symptoms correlated significantly with reduction in NVP ( R2=0.72 , P<.001 ). Conclusion . This is the first study to demonstrate that management of HB/RF can reduce the severity of NVP.
Gill, S. K., Maltepe, C., Mastali, K., & Koren, G. (2009). The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy. Obstetrics and Gynecology International, 2009, 1–4. https://doi.org/10.1155/2009/585269