Effect of adrenomedullin on hepatic pericytes (stellate cells) of the rat

Citations of this article
Mendeley users who have this article in their library.


When hepatic stellate cells (Ito cells, fat-storing cells) were incubated with adrenomedullin, they underwent relaxation as monitored by the silicone-rubber membrane method; 43%, 65% and 87% of stellate cells relaxed 5, 10 and 20 min, respectively, after addition of 10-6 M adrenomedullin. Adrenomedullin also triggered the dissociation of F-actin and induced transformation of stellate cells to dendritic cell-like structure. When incubated with 10-6 M of adrenomedullin for 30 min, cellular levels of cAMP increased from the basal value of 10.2 ± 1.4 to 107 ± 2.8 pmol/2 × 105 cells without affecting cGMP levels. The reaction occurred dose-dependently and was inhibited by an antagonist of calcitonin gene-related peptide. Adrenomedullin had negligible effects on DNA and protein synthesis in proliferating stellate cells. Thus, adrenomedullin is a potent relaxing peptide to hepatic stellate cells and may contribute to the regulation of sinusoidal microcirculation. © 1994.




Kawada, N., & Inoue, M. (1994). Effect of adrenomedullin on hepatic pericytes (stellate cells) of the rat. FEBS Letters, 356(1), 109–113. https://doi.org/10.1016/0014-5793(94)01178-8

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free