The effect of cellular stress on T and B cell memory pathways in immunized and unimmunized BALB/c mice

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Abstract

Immunological memory is a fundamental function of vaccination. The antigenic breakdown products of the vaccine may not persist and undefined tonic stimulation has been proposed to maintain the specific memory. We have suggested that cellular stress agents to which the immune cells are constantly exposed may be responsible for tonic stimulation. Here we have studied 4 stress agents; Na arsenite, an oxidative agent, Gramicidin eliciting K+ efflux and Ca influx, dithiocarbamide a metal ionophore and Alum an immunological adjuvant. The aims of this study is to extend these investigations to T and B cell responses of unimmunised and {OVA} immunised {BALB/c} mice. Furthermore, to ascertain if stress is involved in optimal expression of memory B cells, as demonstrated in {CD4+} T cells. Examination of the homeostatic pathway defined by {IL-15} / {IL15R} (receptor) interaction and the inflammasome pathway defined by the {IL-1-IL1R} interaction between {DC} and {CD4+} T cells suggests that both pathways are involved in the development of optimal expression of {CD4+} {CD45RO+} memory T cells in unimmunised and {OVA} immunised {BALB/c} mice. Furthermore, significant direct correlation was found between {CD4+} {CD44+} memory T cells and both, {IL-15} of the homeostatic and {IL1beta} of the inflammasome pathways. However, {CD19+} {CD27+} memory B cells in vivo seem to utilise only the {IL15/IL15R} homeostatic pathway, though the proliferative responses are enhanced by the stress agents. Altogether, stress agents may upregulate unimmunised and {OVA} immunised {CD4+} {CD44+} memory T cells by the homeostatic and inflammasome pathways. However, the {CD19+} {CD27+} memory B cells utilise only the homeostatic pathway.

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APA

Wang, Y., Rahman, D., Mistry, M., & Lehner, T. (2016). The effect of cellular stress on T and B cell memory pathways in immunized and unimmunized BALB/c mice. Journal of Biological Chemistry, 291(39), 20707–20717. https://doi.org/10.1074/jbc.M116.746057

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