Effect of endodontic cement on bone mineral density using serial dual-energy x-ray absorptiometry

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Introduction Materials with new compositions were tested in order to develop dental materials with better properties. Calcium silicate-based cements, including white mineral trioxide aggregate (WMTA), may improve osteopromotion because of their composition. Nano-modified cements may help researchers produce ideal root-end filling materials. Serial dual-energy x-ray absorptiometry measurement was used to evaluate the effects of particle size and the addition of tricalcium aluminate (C3A) to a type of mineral trioxide aggregate-based cement on bone mineral density and the surrounding tissues in the mandible of rabbits. Methods Forty mature male rabbits (N = 40) were anesthetized, and a bone defect measuring 7 × 1 × 1 mm was created on the semimandible. The rabbits were divided into 2 groups, which were subdivided into 5 subgroups with 4 animals each based on the defect filled by the following: Nano-WMTA (patent application #13/211.880), WMTA (as standard), WMTA without C3A, Nano-WMTA + 2% Nano-C3A (Fujindonjnan Industrial Co, Ltd, Fujindonjnan Xiamen, China), and a control group. Twenty and forty days postoperatively, the animals were sacrificed, and the semimandibles were removed for DXA measurement. Results The Kruskal-Wallis test followed by the Mann-Whitney U test showed significant differences between the groups at a significance level of P <.05. P values calculated by the Kruskal-Wallis test were.002 for bone mineral density at both intervals and P20 day =.004 and P40 day =.005 for bone mineral content. Conclusions This study showed that bone regeneration was enhanced by reducing the particle size (nano-modified) and C3A mixture. This may relate to the existence of an external supply of minerals and a larger surface area of nano-modified material, which may lead to faster release rate of Ca2+, inducing bone formation. Adding Nano-C3A to Nano-WMTA may improve bone regeneration properties. © 2014 American Association of Endodontists.




Saghiri, M. A., Orangi, J., Tanideh, N., Janghorban, K., & Sheibani, N. (2014). Effect of endodontic cement on bone mineral density using serial dual-energy x-ray absorptiometry. Journal of Endodontics, 40(5), 648–651. https://doi.org/10.1016/j.joen.2013.11.025

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