The exact underlying mecha- nism regulating the human post-ejacu- latory refractory period is not yet known. The main finding of previous research has been an occurrence of surge-like increas- es in plasma prolactin and oxytocin levels immediately after orgasm. However, recent advances in neuroendocrinology have re- sulted in the identification of a new pep- tide, the gonadotropin inhibitory hormone (GnIH), which is considered to inhibit the hypothalamic-pituitary-gonadal axis and sexual functions. This paper hypothesizes that GnIH causes refractoriness of the post-ejaculatory refractory period, and on the basis of studies on hormonal fluctua- tions at the time of orgasm, we hypothe- size that in addition to its pulsatile pattern of secretion, GnIH might also exhibit a surge-like pattern of secretion.
Pazhoohi, F., & Saied Salehi, M. (2013). Effect of gonadotropin inhibitory hormone (GnIH) secretion on post-ejaculatory refractory period: A hypothesis. Hypothesis, 11(1). https://doi.org/10.5779/hypothesis.v11i1.286