Effect of HbA1ccombined FPG on screening diabetes in health check-up

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Objective: To appraise the effectiveness of HbA1cand fasting plasma glucose (FPG) on screening diabetes in health check-up. Methods: A total of 1 337 individuals (male 850, female 487), aged 27 to 91 years with HbA1ctest were included. Participates with HbA1c≥6.0% or FPG≥6.1 mmol/L underwent oral glucose tolerance test (OGTT). Diabetes mellitus was diagnosed according to the criteria of WHO in 1999, FPG≥7.0 mmol/L and/or OGTT 2 h-postload plasm glucose (2 h-PG)≥11.1 mmol/L. The sensitivity and specificity of HbA1cthresholds and FPG or combination test on screening of diabetes were analyzed. Results: A total of 842 subjects had HbA1c<6.0%, in which 32 had isolated FPG≥6.1 mmol/L, of 495 had HbA1c≥6.0%. Subjects with HbA1c≥6.0% had significant increased disorder indexes than those with HbA1c<6.0%. 527 subjects who had HbA1c≥6.0% or FPG≥6.1 mmol/L underwent OGTT. A total of 234 subjects were newly diagnosed diabetes, including 123 (123/234, 52.56%) with FPG≥7.0 mmol/L, and 111 subjects (111/234, 47.43%) with isolated 2 h-PG≥11.1 mmol/L. Among 234 new diabetes, 91.88% (215 subjects) had HbA1c≥6.3%, and 77.40% (181 subjects) had HbA1c≥6.5%. HbA1c≥6.3% combined FPG ≥7.0 mmol/L increased the positive rate of newly diagnosed diabetes from 91.88% to 96.58%. Conclusions: HbA1cis a practical and convenient tool for screening undiagnosed diabetes in routine health check-up of a large population. Combined use of HbA1c≥6.3% and/or FPG≥7.0 mmol/L is efficient for early detection of diabetes. © 2012 Hainan Medical College.

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Li, L. J., Zhou, J. X., Chen, H. T., Song, Y. L., & Xue, Y. M. (2012). Effect of HbA1ccombined FPG on screening diabetes in health check-up. Asian Pacific Journal of Tropical Medicine, 5(6), 472–475. https://doi.org/10.1016/S1995-7645(12)60081-9

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