Background: The aim of the present study was to determine if long-term use of a cyclooxygenase-2 (COX-2) inhibitor affects fertility or ovulation in female mice. Methods: Twenty-four female mice, 25 days of age, were given a selective COX-2 inhibitor: 3 mg/kg celecoxib (n=8), 5 mg/kg celecoxib (n=8), or placebo (n=8) in a random fashion. Eight female mice, 10-11 weeks old, given 3 mg/kg celecoxib (n=4) or placebo (n=4) were subjected to continuous mating studies. Results: Results from the 24 mice (n=8 for each group) showed that oocyte number was not significantly different between female mice treated with either 3 mg/kg or 5 mg/kg celecoxib and placebo (21.4±2.5, 21.5±3.3, 23.3±3.8, respectively). From the continuous mating study, the litter size of female mice treated with celecoxib was not significantly different (8.2±1.3 pups/litter) compared to those treated with placebo (8.3±1.2 pups/litter). In addition, female mice treated with celecoxib had an average of 2.8±0.5 litters in a 12-week period, which was similar to female mice treated with placebo (3.0±0.8 litters/female). Conclusion: This study suggests that use of low-dose (≤5 mg/kg) selective COX-2 inhibitor in a mouse model does not significantly impair the female reproductive function. © 2007 Elsevier. All rights reserved.
Wang, P. H., Horng, H. C., Chen, Y. J., Hsieh, S. L., Chao, H. T., & Yuan, C. C. (2007). Effect of a selective nonsteroidal anti-inflammatory drug, celecoxib, on the reproductive function of female mice. Journal of the Chinese Medical Association, 70(6), 245–248. https://doi.org/10.1016/S1726-4901(09)70367-3