Effect of a selective nonsteroidal anti-inflammatory drug, celecoxib, on the reproductive function of female mice

5Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

Background: The aim of the present study was to determine if long-term use of a cyclooxygenase-2 (COX-2) inhibitor affects fertility or ovulation in female mice. Methods: Twenty-four female mice, 25 days of age, were given a selective COX-2 inhibitor: 3 mg/kg celecoxib (n=8), 5 mg/kg celecoxib (n=8), or placebo (n=8) in a random fashion. Eight female mice, 10-11 weeks old, given 3 mg/kg celecoxib (n=4) or placebo (n=4) were subjected to continuous mating studies. Results: Results from the 24 mice (n=8 for each group) showed that oocyte number was not significantly different between female mice treated with either 3 mg/kg or 5 mg/kg celecoxib and placebo (21.4±2.5, 21.5±3.3, 23.3±3.8, respectively). From the continuous mating study, the litter size of female mice treated with celecoxib was not significantly different (8.2±1.3 pups/litter) compared to those treated with placebo (8.3±1.2 pups/litter). In addition, female mice treated with celecoxib had an average of 2.8±0.5 litters in a 12-week period, which was similar to female mice treated with placebo (3.0±0.8 litters/female). Conclusion: This study suggests that use of low-dose (≤5 mg/kg) selective COX-2 inhibitor in a mouse model does not significantly impair the female reproductive function. © 2007 Elsevier. All rights reserved.

Cite

CITATION STYLE

APA

Wang, P. H., Horng, H. C., Chen, Y. J., Hsieh, S. L., Chao, H. T., & Yuan, C. C. (2007). Effect of a selective nonsteroidal anti-inflammatory drug, celecoxib, on the reproductive function of female mice. Journal of the Chinese Medical Association, 70(6), 245–248. https://doi.org/10.1016/S1726-4901(09)70367-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free