Effect of transforming growth factor β on fibroblasts in three-dimensional lattice cultures

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Abstract

Human skin fibroblasts were cultivated in three-dimensional fibrin or collagen lattices, under retracting or non-retracting conditions, and the influence of transforming growth factor β (TGFβ) was tested. TGFβ stimulated the synthesis of non-collagen protein and of collagen in all the systems. However, only in non-retracting fibrin lattices did it restore a level of protein synthesis comparable to that found in monolayers. The effects of TGFβ greatly depended on the type of substratum and on the presence or absence of retraction. © 1990.

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Coustry, F., Gillery, P., Maquart, F. X., & Borel, J. P. (1990). Effect of transforming growth factor β on fibroblasts in three-dimensional lattice cultures. FEBS Letters, 262(2), 339–341. https://doi.org/10.1016/0014-5793(90)80223-6

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