Thousands of Bangladeshi are suffering from arsenic-induced keratosis<br />affecting palms and soles. Palmer keratosis, particularly in young female,<br />affects the socioeconomic condition. Till today there is no effective treatment.<br />Twenty patients of mild to moderate degree of arsenical palmer keratosis were<br />treated with garlic oil in soft capsule (10 mg) daily orally for 12 weeks. Similar<br />treatment was given to 17 arsenic exposed controls and 15 healthy volunteers<br />for comparison. Effectiveness of treatment was evaluated by change in the<br />clinical score of palmer keratosis and amount of total arsenic in nail after 12<br />weeks. The mean (± SD) clinical scoring of patients before treatment was 102.8<br />± 19.0. It was reduced to 36.0 ± 8.7 after completion of treatment (65%<br />reduction). The mean amounts of total arsenic in nail of patients and arsenic<br />exposed controls were 13 to 14-fold higher in comparison to healthy<br />volunteers. Treatment with garlic oil reduced about 50% of the total arsenic<br />accumulated in nails. Common adverse effects were garlic smell and gastric<br />irritation. However, there was no drop out case due to these adverse effects.<br />Oral administration of garlic oil improves symptom of arsenical palmer<br />keratosis with reduction in body arsenic load.
Misbahuddin, M., Bashar, T., & Hossain, M. A. (2012). Effectiveness of garlic oil in the treatment of arsenical palmer keratosis. Bangladesh Journal of Pharmacology, 8(1), 22–27. https://doi.org/10.3329/bjp.v8i1.13121