Manipulations of rearing conditions have been used to examine the effects of early experience on adult behavior with varying results. Evidence suggests that postnatal days (PND) 15-21 are a time of particular susceptibility to environmental influences on anxiety-like behavior in mice. To examine this, we subjected C57BL/6J and DBA/2J mice to an early handling-like procedure. Pups were separated from dams from PND 12-20 for 30 minutes daily or received standard care. On PND 21, pups were weaned and either individually- or group- housed. On PND 60, anxiety-like behavior was examined on the elevated zero-maze. Although individually- housed animals took longer to enter an open quadrant of the maze, they spent more time in the open than group-housed animals. Additionally, we observed a trend of reduced anxiety-like behavior in C57BL/6J, but not DBA/2J mice that underwent the handling-like procedure. © 2011 Flanigan, Cook.




T.J., F., & M.N., C. (2011). Effects of an early handling-like procedure and individual housing on anxiety-like behavior in adult C57BL/6J and DBA/2J mice. PLoS ONE, 6(4). https://doi.org/10.1371/journal.pone.0019058 LK  - http://sfx.library.uu.nl/utrecht?sid=EMBASE&issn=19326203&id=doi:10.1371%2Fjournal.pone.0019058&atitle=Effects+of+an+early+handling-like+procedure+and+individual+housing+on+anxiety-like+behavior+in+adult+C57BL%2F6J+and+DBA%2F2J+mice&stitle=PLoS+ONE&title=PLoS+ONE&volume=6&issue=4&spage=&epage=&aulast=Flanigan&aufirst=Timothy+J.&auinit=T.J.&aufull=Flanigan+T.J.&coden=&isbn=&pages=-&date=2011&auinit1=T&auinitm=J

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