Effects of lead acetate on testicular function and caspase-3 expression with respect to the protective effect of cinnamon in albino rats

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Abstract

The aim of this study was to investigate the protective effects of cinnamon on lead acetate induced reproductive toxicities in rats. Thirty-two male rats were randomly divided into 4 groups, 8 rats in each. Control rats received distilled water, while treated rats received lead acetate (30. mg/kg), cinnamon (250. mg/kg) and lead acetate and cinnamon (30. mg/kg and 250. mg/kg) for 60 days by gavage tube. In cinnamon treated rats, the relative weights of testes, epididymis, seminal and prostate glands were significantly (P<0.05) increased compared with that in lead acetate treated rats. Sperm cell concentration and viability were significantly (P<0.05) reduced, while sperm abnormalities were significantly (P<0.05) increased in lead treated rats. The superoxide dismutase (SOD) and catalase activities were significantly reduced (P<0.001) in lead acetate treated rats compared to the other groups, while the addition of cinnamon to lead acetate improved the level of SOD compared to the lead treated group. There was a marked reduction (P<0.001) in the expression of androgen receptor and significant (P<0.001) increase in the level of caspase-3 protein expression in the testis of lead treated rats. In conclusion, cinnamon exhibited protective effect on reproductive system by inhibiting lead acetate induced oxidative stress and excessive cell apoptosis.

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Elgawish, R. A. R., & Abdelrazek, H. M. A. (2014). Effects of lead acetate on testicular function and caspase-3 expression with respect to the protective effect of cinnamon in albino rats. Toxicology Reports, 1, 795–801. https://doi.org/10.1016/j.toxrep.2014.10.010

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