Objective: To investigate the effects of standardized soy extract on climacteric symptoms, lipid profiles, bone markers, and serum isoflavone concentration in healthy Taiwanese postmenopausal women. Materials and Methods: A multicenter, open-labeled, randomized, prospective, comparative study design was used. A total of 130 outpatients who had undergone natural menopause were randomly administered either 70 mg or 35 mg soy extract daily for 24 weeks. Results: The evidence suggests that the soy extract treatment that was administered to both groups for 1 month could help reduce climacteric scores (reductions of 19.66% [p< 0.01] and 18.85% [p< 0.01] in the 35 mg and 70 mg groups compared with baseline, respectively), and the efficacy was more potent after 6 months of treatment. Soy isoflavone significantly reduced the total cholesterol (reductions of 4.50% [p< 0.01] and 3.06% [p< 0.05] in the 35 mg and 70 mg groups, respectively) and low density lipoprotein cholesterol levels (reductions of 4.67% [p< 0.05] and 5.09% [p< 0.05] in the 35 mg and 70 mg groups, respectively) in patients with total cholesterol > 200 mg/dL after 6 months of treatment. In patients with high bone turnover (urinary deoxypyridinoline/creatinine > 7.4. nM/mM), soy extract treatment reduced the deoxypyridinoline /creatinine level by 10.53% (p< 0.05) and 11.58% (p< 0.05) in the 35 mg and 70 mg groups, respectively. Serum levels of isoflavone increased in both groups after 6 months of treatment. Conclusion: Soy extract is highly efficacious at relieving menopausal symptoms and demonstrates a positive effect on the cardiovascular system and skeleton. © 2012 .
Yang, T. S., Wang, S. Y., Yang, Y. C., Su, C. H., Lee, F. K., Chen, S. C., … Huang, K. E. (2012). Effects of standardized phytoestrogen on Taiwanese menopausal women. Taiwanese Journal of Obstetrics and Gynecology, 51(2), 229–235. https://doi.org/10.1016/j.tjog.2012.04.011