Efficacy and safety of silodosin in the treatment of lower urinary tract symptoms in elderly men taking antihypertensive medications

  • Choi W.S.
  • Cho M.C.
  • Lee J.W.
  • et al.
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Abstract

Background Both hypertension and lower urinary tract symptoms (LUTS) are common conditions in the elderly population. This study investigated the efficacy and safety of silodosin in the treatment of LUTS in elderly men who were taking antihypertensive medications. Methods This is an observational study which collected the medical records of patients who started silodosin medication for their LUTS between April 2015 and December 2015. Inclusion criteria were age >= 65 years, currently taking antihypertensive medication, and International Prostate Symptom Score (IPSS) >= 8. Pretreatment evaluation included IPSS, Male Sexual Health Questionnaire, systemic symptoms, blood pressure, and uroflowmetry. Post-treatment evaluation was performed 3 months after the initial administration of silodosin medication. Results Mean age of the total 48 patients was 70.7 +/- 5.2 years. Thirty-two (66.7%) patients who continued silodosin single treatment showed a significant decrease in IPSS Quality of life scores (4.2 +/- 1.1 vs. 3.0 +/- 1.6, P = 0.001) and an increase in the maximum flow rate (10.7 +/- 6.0 mL/s vs. 14.0 +/- 4.5 mL/s, P = 0.001). Blood pressures did not change, and none of the patients needed to adjust their antihypertensive medication. New development of orthostatic hypotension was observed in one (2.5%) patient. Among the six patients who had orthostatic hypotension before silodosin treatment, none of the patients showed symptom aggravation. Ejaculatory dysfunction that required discontinuation of silodosin medication developed in only one (2.5%) patient. Conclusion Silodosin is an effective and safe agent in elderly men who are taking antihypertensive medications. Silodosin has an advantage in the treatment of LUTS in this population, even if the patients have orthostatic hypotension before treatment.Copyright © 2017

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Choi W.S., Cho M.C., Lee J.W., Song S.H., Oh J.K., Lee S.W., … Park J.Y. (2017). Efficacy and safety of silodosin in the treatment of lower urinary tract symptoms in elderly men taking antihypertensive medications. Prostate International, 5(3), 113–118. https://doi.org/10.1016/j.prnil.2017.02.001

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