Electronic cigarettes efficacy and safety at 12 months: Cohort study

  • L. M
  • M.E. F
  • M. F
  • et al.
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Abstract

Objective: To evaluate the safety and efficacy as a tool of smoking cessation of electronic cigarettes (e-cigarettes), directly comparing users of e-cigarettes only, smokers of tobacco cigarettes only, and smokers of both. Design: Prospective cohort study. Final results are expected in 2019, but given the urgency of data to support policies on electronic smoking, we report the results of the 12-month follow-up. Data Sources: Direct contact and structured questionnaires by phone or via internet. Methods: Adults (30-75 years) were included if they were smokers of > 1 tobacco cigarette/day (tobacco smokers), users of any type of e-cigarettes, inhaling >50 puffs weekly (e-smokers), or smokers of both tobacco and e-cigarettes (dual smokers). Carbon monoxide levels were tested in a sample of those declaring tobacco smoking abstinence. Main Outcome Measures: Sustained smoking abstinence from tobacco smoking at 12 months, reduction in the number of tobacco cigarettes smoked daily. Data Synthesis: We used linear and logistic regression, with region as cluster unit. Results: Follow-up data were available for 236 e-smokers, 491 tobacco smokers, and 232 dual smokers (overall response rate 70.8%). All e-smokers were tobacco ex-smokers. At 12 months, 61.9% of the e-smokers were still abstinent from tobacco smoking; 20.6% of the tobacco smokers and 22.0% of the dual smokers achieved tobacco abstinence. Adjusting for potential confounders, tobacco smoking abstinence or cessation remained significantly more likely among e-smokers (adjusted OR 5.19; 95% CI: 3.35-8.02), whereas adding e-cigarettes to tobacco smoking did not enhance the likelihood of quitting tobacco and did not reduce tobacco cigarette consumption. E-smokers showed a minimal but significantly higher increase in self-rated health than other smokers. Non significant differences were found in self-reported serious adverse events (eleven overall). Conclusions: Adding e-cigarettes to tobacco smoking did not facilitate smoking cessation or reduction. If e-cigarette safety will be confirmed, however, the use of e-cigarettes alone may facilitate quitters remaining so. Registration Number: NCT01785537.

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APA

L., M., M.E., F., M., F., C., L. V., C., M., M.R., G., … W., R. (2015). Electronic cigarettes efficacy and safety at 12 months: Cohort study. PLoS ONE. Public Library of Science (E-mail: plos@plos.org). Retrieved from http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0129443&representation=PDF http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emex&NEWS=N&AN=605098355

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