Softness really is the hard force! Reported here was the critical yet long-overlooked role of electronic polarizability (i.e., softness) effect in controlling absolute stereochemical courses of general asymmetric induction events. Thus, a sensitive dependence of the sense of chiral induction on an alkene substrate's substituent electronic polarizability character was uncovered from a range of structurally highly comparable Sharpless asymmetric dihydroxylation (AD) systems, from which a new polarizability-based stereochemical model of predictive power was suggested. © 2011 Elsevier Ltd. All rights reserved.
CITATION STYLE
Han, P., Wang, R., & Wang, D. Z. (2011). Electronic polarizability-based stereochemical model for Sharpless AD reactions. Tetrahedron, 67(46), 8873–8878. https://doi.org/10.1016/j.tet.2011.09.073
Mendeley helps you to discover research relevant for your work.