Electrophoretically defined myosin heavy chain patterns of single human muscle spindles

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Abstract

At least four myosin heavy chain (MHC) isoforms were separated by SDS-PAGE in extracts of intrafusal fibers isolated by microdissection from human lumbrical muscles. The fastest migrating MHC represents a slow isoform. The slowest migrating MHC was identified as the embryonic MHCemb. A faint band, moving slightly faster than MHCemb, most likely represents a neonatal/fetal MHC isoform. A prominent band, moving between the latter and the slow isoform is suggested to represent a hitherto unidentified, spindle-specific MHC isoform, MHCif. © 1993.

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Pedrosa-Domellöf, F., Gohlsch, B., Thornell, L. E., & Pette, D. (1993). Electrophoretically defined myosin heavy chain patterns of single human muscle spindles. FEBS Letters, 335(2), 239–242. https://doi.org/10.1016/0014-5793(93)80737-F

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