Eligibility for isoniazid preventive therapy in South African gold mines

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Setting: The "Thibela TB" cluster randomised trial of community-wide isoniazid preventive therapy (IPT) to reduce tuberculosis incidence in the South African gold mines. Objectives: To determine the proportion of participants eligible for IPT and the reasons and risk factors for ineligibility, to inform the scale-up of IPT. Design: Cross-sectional survey of participants in intervention clusters (mine shafts) consenting to tuberculosis screening and assessment for eligibility to start IPT. Results: Among 27,126 consenting participants, 94.7% were male, the median age was 41 years, 12.2% reported previous tuberculosis, 0.6% reported ever taking IPT and 2.5% reported currently taking antiretroviral therapy. There were 24,430 (90.1%) assessed as eligible to start IPT, of whom 23,659 started IPT. The most common reasons for ineligibility were having suspected tuberculosis that was subsequently confirmed by a positive smear and/or culture (n=705), excessive alcohol consumption (n=427) and being on tuberculosis treatment at time of initial screen (n=241). Ineligibility was associated with factors including older age, female gender, prior history of tuberculosis and being in "HIV care". However, at least 78% were eligible for IPT in all of these sub-groups. Conclusions: The vast majority of participants in this community-wide intervention were eligible for IPT. © 2013 Lewis et al.




Lewis, J. J., Fielding, K. L., Grant, A. D., Chihota, V. N., Popane, F., Luttig, M., … Churchyard, G. J. (2013). Eligibility for isoniazid preventive therapy in South African gold mines. PLoS ONE, 8(11). https://doi.org/10.1371/journal.pone.0081376

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