The Elusive Nature of White Matter Damage in Anatomo-Clinical Correlations

  • Bartolomeo P
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Comments on an article by P. Molenberghs, M. V. Sale & J. B. Mattingley (see record [rid]2012-19746-001[/rid]). The current authors reports that Molenberghs et al. contributed a clearly written meta-analysis on the debated issue of the anatomy of spatial neglect. As the authors acknowledge in the general discussion, while their method based on 'the peak coordinates of the critical lesion site' is certainly appropriate for gray matter lesions, it seems problematic for long-range white matter bundles. At variance with gray matter lesions, where one can look for maximum overlap or analogous topological data, lesions in different sectors along a long-range white matter fascicle can produce similar effects by disconnecting the fascicle, independent of the precise location of the interruption. Despite these caveats, Molenberghs et al.'s results did reveal that 'the largest region involved in the development of spatial neglect was a white matter lesion corresponding to the superior longitudinal fasciculus'. (PsycINFO Database Record (c) 2016 APA, all rights reserved)




Bartolomeo, P. (2012). The Elusive Nature of White Matter Damage in Anatomo-Clinical Correlations. Frontiers in Human Neuroscience, 6.

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