Interference with the alternative splicing of apoptotic factors offers an innovative and specific mechanism to target malignant cells. In this issue of Chemistry & Biology, Zhou et al.  report on the regulation of the alternative splicing of Bcl-x pre-mRNA in response to emetine, a potent protein synthesis inhibitor, as well as define a major player in the signaling mechanism. © 2007 Elsevier Ltd. All rights reserved.
Shultz, J. C., & Chalfant, C. E. (2007, December 26). Emetine and the Alternative Splicing of Bcl-X: Where to next? Chemistry and Biology. https://doi.org/10.1016/j.chembiol.2007.12.002