Emmetropization and optical aberrations in a myopic corneal refractive surgery chick model

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Abstract

We studied the potential of myopic corneal refractive laser surgery to induce myopia (axial elongation) and potential interactions between aberrations (generally resulting from the procedure) and myopia development in chicks (Gallus domesticus). Ten white Leghorn chicks were monolaterally treated one day post-hatching with photorefractive keratectomy (PRK), with a nominal dioptric change of -9.9 D (imposed hyperopia). Axial length was measured using an adapted ultrasonic biometer; corneal radius of curvature was measured using a custom-built videokeratometer and spherical error and high order aberrations were measured using custom-built Hartmann-Shack aberrometer post-operatively on days 9, 12, 14 and 16 after hatching. Two-weeks after surgery, there were no significant differences in corneal radius of curvature between treated and control eyes. Astigmatism increased on average by a factor of 2.6 and 3rd and higher order aberrations by a factor of 4.3 after PRK. Both treated and control eyes were close to emmetropia, and no axial elongation was found in the treated eyes. The inability of the refractive procedure to achieve significant reductions in the corneal power could be attributed to the biomechanical properties of the chick eye. High order aberrations induced significant contrast decrease (by a factor of 1.7 at 4.5 c/deg). However, reduced image quality neither produced myopic refractive error nor axial elongation in the treated eyes. Both normal and treated eyes emmetropized, indicating that increased amounts of aberrations do not appear to be a risk factor for myopia. © 2007 Elsevier Ltd. All rights reserved.

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Cera, E. G. de la, Rodríguez, G., de Castro, A., Merayo, J., & Marcos, S. (2007). Emmetropization and optical aberrations in a myopic corneal refractive surgery chick model. Vision Research, 47(18), 2465–2472. https://doi.org/10.1016/j.visres.2007.06.005

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