Spatial computer simulations are becoming more feasible and relevant for studies of signaling pathways due to technical advances in experimental techniques yielding better high resolution data. However, many common single particle simulation <br />environments used in computational systems biology lack the functionality to easily implement spatially heterogeneous membrane environments.
Seeliger, C., & Le Novère, N. (2015). Enabling surface dependent diffusion in spatial simulations using Smoldyn. BMC Research Notes, 8(1). https://doi.org/10.1186/s13104-015-1723-6