Encapsulation as a Strategy for the Design of Biological Compartmentalization

Citations of this article
Mendeley users who have this article in their library.


Compartmentalization is one of the defining features of life. Through intracellular spatial control, cells are able to organize and regulate their metabolism. One of the most broadly used organizational principles in nature is encapsulation. Cellular processes can be encapsulated within either membrane-bound organelles or proteinaceous compartments that create distinct microenvironments optimized for a given task. Further challenges addressed through intracellular compartmentalization are toxic or volatile pathway intermediates, slow turnover rates and competing side reactions. This review highlights a selection of naturally occurring membrane- and protein-based encapsulation systems in microbes and their recent applications and emerging opportunities in synthetic biology. We focus on examples that use engineered cellular organization to control metabolic pathway flux for the production of useful compounds and materials.




Giessen, T. W., & Silver, P. A. (2016, February 27). Encapsulation as a Strategy for the Design of Biological Compartmentalization. Journal of Molecular Biology. Academic Press. https://doi.org/10.1016/j.jmb.2015.09.009

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free