Retinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors. Although the location, concentration and roles of endogenous retinoic acid in post-natal kidneys are poorly defined, there is accumulating evidence linking post-natal vitamin A deficiency to impaired renal concentrating and acidifying capacity associated with increased susceptibility to urolithiasis, renal inflammation and scarring. The aim of this study is to examine the presence and the detailed localization of endogenous retinoic acid activity in neonatal, young and adult mouse kidneys, to establish a fundamental ground for further research into potential target genes, as well as physiological and pathophysiological roles of endogenous retinoic acid in the post-natal kidneys.
Wong, Y. F., Kopp, J. B., Roberts, C., Scambler, P. J., Abe, Y., Rankin, A. C., … Xu, Q. (2011). Endogenous retinoic acid activity in principal cells and intercalated cells of mouse collecting duct system. PLoS ONE, 6(2). https://doi.org/10.1371/journal.pone.0016770