Endoplasmic reticulum stress in liver disease

Abstract

Endoplasmic reticulum stress (ERS) is an important self-defense mechanism of the cell. ERS initially activates survival pathway, but sustained ERS will induce apoptosis. ERS and apoptosis induced by ERS are involved in the pathogenesis of many liver diseases, including viral hepatitis, alcohol-induced liver injury, nonalcoholic fatty liver disease, drug-induced liver disease, acute hepatic failure, and hepatocellular carcinoma. It is of important theoretical and practical significance for curing liver diseases to find some new drugs targeting ERS-induced apoptosis. The present review will discuss the survival and death pathways mediated by ERS, the role of ERS in the pathogenesis of hepatic diseases, and therapeutic interventions for these diseases.