Endoscopic diagnosis of primary anorectal melanoma

  • Sheng W
  • Siyu S
  • Xiang L
  • et al.
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Objective: The present study retrospectively analyzed case data from 12 patients diagnosed with anorectal melanoma, with the purpose of identifying key diagnostic features at endoscopy. Materials and Methods: Images from colonoscopy were reviewed for all patients in order to establish the endoscopic features of primary anorectal melanoma. For the patients whose colonoscopic examinations included endoscopic ultrasound, images were examined to characterize lesions and the depth of infiltration, the results of which were compared with pathological findings after operative resection. Results: At colonoscopy, superficial melanin pigmentation was identified in 10 patients with anorectal melanoma, with morphology including spots, patches, or sheets of pigmentation. In patients who underwent endoscopic ultrasound, lesions appeared as masses on the mucosal side with inhomogeneous or low-level internal echoes or ulcer-type lesions invading the muscularis propria. Lesions diagnosed as anorectal melanoma also demonstrated irregular margins and varying degrees of submucosal infiltration. Infiltration depth of melanoma via endoscopic ultrasound (EUS) was concordant with surgical pathology results in 100% of patients. Conclusion: Colonoscopy combined with biopsy and subsequent pathological examination can accurately diagnose primary anorectal melanoma. Moreover, EUS is a reliable tool for assessing the depth of infiltration of this disease. © Sheng et al.




Sheng, W., Siyu, S., Xiang, L., Nan, G., Guoxin, W., Jintao, G., … Shupeng, W. (2017). Endoscopic diagnosis of primary anorectal melanoma. Oncotarget, 8(30), 50133–50140. https://doi.org/10.18632/oncotarget.15495

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