The vasculature of the bone marrow remains poorly characterized, yet crucial to maintain hematopoiesis and retain stem cells in a quiescent state. A recent study by Itkin et al. (2016) in Nature reports how vascular barrier integrity and endothelial cell metabolism regulate hematopoietic stem cell quiescence and leukocyte trafficking.
Harjes, U., Verfaillie, C., & Carmeliet, P. (2016, May 9). Endothelial Barrier and Metabolism: New Kids on the Block Regulating Bone Marrow Vascular Niches. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2016.04.016