Tumor cells are characterized by accelerated growth usually accompanied by up-regulated pathways that ultimately increase the rate of ATP production. These cells can suffer metabolic reprogramming, resulting in distinct bioenergetic phenotypes, generally enhancing glycolysis channeled to lactate production. In the present work we showed metabolic reprogramming by means of inhibitors of histone deacetylase (HDACis), sodium butyrate and trichostatin. This treatment was able to shift energy metabolism by activating mitochondrial systems such as the respiratory chain and oxidative phosphorylation that were largely repressed in the untreated controls.
Amoêdo, N. D., Rodrigues, M. F., Pezzuto, P., Galina, A., da Costa, R. M., de Almeida, F. C. L., … David Rumjanek, F. (2011). Energy metabolism in H460 lung cancer cells: Effects of histone deacetylase inhibitors. PLoS ONE, 6(7). https://doi.org/10.1371/journal.pone.0022264