Engineered swine models of cancer

15Citations
Citations of this article
50Readers
Mendeley users who have this article in their library.

Abstract

Over the past decade, the technology to engineer genetically modified swine has seen many advancements, and because their physiology is remarkably similar to that of humans, swine models of cancer may be extremely valuable for preclinical safety studies as well as toxicity testing of pharmaceuticals prior to the start of human clinical trials. Hence, the benefits of using swine as a large animal model in cancer research and the potential applications and future opportunities of utilizing pigs in cancer modeling are immense. In this review, we discuss how pigs have been and can be used as a biomedical models for cancer research, with an emphasis on current technologies. We have focused on applications of precision genetics that can provide models that mimic human cancer predisposition syndromes. In particular, we describe the advantages of targeted gene-editing using custom endonucleases, specifically TALENs and CRISPRs, and transposon systems, to make novel pig models of cancer with broad preclinical applications.

Cite

CITATION STYLE

APA

Watson, A. L., Carlson, D. F., Largaespada, D. A., Hackett, P. B., & Fahrenkrug, S. C. (2016, May 9). Engineered swine models of cancer. Frontiers in Genetics. Frontiers Media S.A. https://doi.org/10.3389/fgene.2016.00078

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free