Enhanced cell therapy strategy to treat chronic limb-threatening ischemia

5Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

Intermittent programmed compression of the chronically ischemic limb is associated with arteriogenesis. However, progenitor cell elements contributing to this neovascularization are typically diminished in number and function in the elderly dysvascular patient, particularly in the presence of diabetes, renal insufficiency, and cardiac disease. Granulocyte-colony stimulation factor (G-CSF) dramatically boosts the circulating progenitor cell count. G-CSF was administered in 2 patients being treated for ischemic wounds with an intermittent programmed pneumatic compression device (PPCD). Both had comorbidities associated with diminished circulating progenitor cell counts. Remarkable clinical, hemodynamic, and angiographic improvement was observed. Further study of this synergistic strategy is warranted. © 2010 Society for Vascular Surgery.

Cite

CITATION STYLE

APA

Eton, D., & Yu, H. (2010). Enhanced cell therapy strategy to treat chronic limb-threatening ischemia. Journal of Vascular Surgery, 52(1), 199–204. https://doi.org/10.1016/j.jvs.2009.12.048

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free