Epithelial plasticity is crucial during embryonic development and progression of carcinomas. In this issue, Abell et al. (2011) show that acetylation on histones H2A/H2B prevents epithelial cells from undergoing epithelial-to-mesenchymal transition (EMT). Their findings also suggest that under conditions where EMT and stemness coexist, they can be independently regulated. © 2011 Elsevier Inc.
Heredia, F., & Nieto, M. A. (2011, May 6). An epigenetic mark that protects the epithelial phenotype in health and disease. Cell Stem Cell. https://doi.org/10.1016/j.stem.2011.04.011