Epithelial cells must polarize and establish apical and basolateral membrane domains during development. Recent experiments have shed light on how apical-basal polarity is generated during cellularization in Drosophila, when around 6000 epithelial cells are created synchronously from a syncytium.
Knoblich, J. A. (2000, November 2). Epithelial polarity: The ins and outs of the fly epidermis. Current Biology. Elsevier Ltd. https://doi.org/10.1016/S0960-9822(00)00761-2