A mutation in the cell division gene ftsK causes super-induction of σ70-dependent stress defense genes, such as uspA, during entry of cells into stationary phase. In contrast, we report here that stationary phase induction of σS-dependent genes, uspB and cfa, is attenuated and that σS accumulates at a lower rate in ftsK1 cells. Ectopic overexpression of rpoS restored induction of the rpoS regulon in the ftsK mutant, as did a deletion in the recA gene. Thus, a mutation in the cell division gene, ftsK, uncouples the otherwise coordinated induction of σS-dependent genes and the universal stress response gene, uspA, during entry into stationary phase. © 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Diez, A. A., Tunlid, A., & Nyström, T. (2002). The Escherichia coli ftsK1 mutation attenuates the induction of σS-dependent genes upon transition to stationary phase. FEMS Microbiology Letters, 206(1), 19–23. https://doi.org/10.1016/S0378-1097(01)00509-2