Communication between the ATPase and substrate binding domains of Hsp70 is critical for regulated interaction between this molecular chaperone and its client proteins. In this issue of Molecular Cell, Jiang et al. (2005) report the structure of an intact Hsp70, revealing critical interactions between the two domains. Copyright ©2005 by Elsevier Inc.
D’Silva, P., Marszalek, J., & Craig, E. A. (2005, November 23). An essential connection: Link between Hsp70’s domains at last. Molecular Cell. https://doi.org/10.1016/j.molcel.2005.11.007