Estradiol valerate and alcohol intake: Dose-response assessments

11Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Background: An injection of estradiol valerate (EV) provides estradiol for a prolonged period. Recent research indicates that a single 2.0 mg injection of EV modifies a female rat's appetite for alcoholic beverages. This research extends the initial research by assessing 8 doses of EV (from .001 to 2.0 mg/female rat), as well assessing the effects of 2.0 mg EV in females with ovariectomies. Results: With the administration of EV, there was a dose-related loss of bodyweight reaching the maximum loss, when it occurred, at about 4 days after injections. Subsequently, rats returned to gaining weight regularly. Of the doses tested, only the 2.0 mg dose produced a consistent increase in intake of ethanol during the time previous research indicated that the rats would show enhanced intakes. There was, however, a dose-related trend for smaller doses to enhance intakes. Rats with ovariectomies showed a similar pattern of effects, to intact rats, with the 2 mg dose. After extensive histories of intake of alcohol, both placebo and EV-treated females had estradiol levels below the average measured in females without a history of alcohol-intake. Conclusion: The data support the conclusion that pharmacological doses of estradiol can produce enduring changes that are manifest as an enhanced appetite for alcoholic beverages. The effect can occur among females without ovaries. © 2007 Quirarte et al; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Quirarte, G. L., Reid, L. D., Sofía, I. S., Reid, M. L., Sánchez, M. A., Díaz-Trujillo, A., … Prado-Alcalá, R. A. (2007). Estradiol valerate and alcohol intake: Dose-response assessments. BMC Pharmacology, 7. https://doi.org/10.1186/1471-2210-7-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free