Estrogen is an established endometrial carcinogen. One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen receptor alpha gene (ESR1) is associated with endometrial cancer risk.
Wedrén, S., Lovmar, L., Humphreys, K., Magnusson, C., Melhus, H., Syvänen, A. C., … Weiderpass, E. (2008). Estrogen receptor alpha gene polymorphism and endometrial cancer risk - A case-control study. BMC Cancer, 8. https://doi.org/10.1186/1471-2407-8-322