Estrogen receptor alpha gene polymorphisms and first-ever intracerebral hemorrhage

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Abstract

Signaling through estrogen receptor alpha (ER alpha) regulates vasodilatation and atherogenesis. Since hypertension and atherosclerosis are major mechanisms in stroke development, we hypothesized that genetic variants of the ER alpha gene (ESR1) are determinants of future ischemic stroke or intracerebral hemorrhage (ICH).

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Strand, M., Söderström, I., Wiklund, P. G., Hallmans, G., Weinehall, L., Söderberg, S., & Olsson, T. (2007). Estrogen receptor alpha gene polymorphisms and first-ever intracerebral hemorrhage. Cerebrovascular Diseases, 24(6), 500–508. https://doi.org/10.1159/000110419

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